前十大证券公司排名让你上瘾的咖啡因，就是这样杀死你的健康的。

前十大证券公司排名

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· 俗话说，不谈剂量只谈危害，本就缺乏科学依据。网络上不少为咖啡辟谣的内容，往往刻意忽略咖啡因摄入总量，一味片面宣扬咖啡完全无害。

· 如今咖啡早已融入大众日常生活，很多人习惯饮用高浓度咖啡。再加上日常茶饮、碳酸饮料中也含有咖啡因，越来越多人长期存在咖啡因过量摄入的问题，在不知不觉间损害身体健康。本身患有胃病、肝脏代谢疾病，或是免疫力低下的人群，受到的负面影响会更加严重。

· 若是一味将咖啡塑造成绝对无害的饮品，这类特殊人群便会放松戒备，忽视咖啡因带来的潜在伤害。进而毫无节制地随意饮用，让自身健康持续暴露在风险之中。

· 咖啡本身是一把双刃剑，利弊并存。把控好饮用的尺度与频率，适度摄入能够对身体产生益处，可一旦长期过量饮用，便会反噬身体，引发多种健康问题。

参考资料：

[1] Zivković R. Coffee and health in the elderly. Acta Med Croatica. 2000;54(1):33-6. PMID: 10914439.

[2] Raaska K, Raitasuo V, Laitila J, Neuvonen PJ. Effect of caffeine-containing versus decaffeinated coffee on serum clozapine concentrations in hospitalised patients. Basic Clin Pharmacol Toxicol. 2004 Jan;94(1):13-8. PMID: 14725610.

[3] Crozier TW, Stalmach A, Lean ME, Crozier A. Espresso coffees, caffeine and chlorogenic acid intake: potential health implications. Food Funct. 2012 Jan;3(1):30-3. doi: 10.1039/c1fo10240k. Epub 2011 Nov 30. PMID: 22130653.

[4] Ludwig IA, Mena P, Calani L, Cid C, Del Rio D, Lean ME, Crozier A. Variations in caffeine and chlorogenic acid contents of coffees: what are we drinking? Food Funct. 2014 Aug;5(8):1718-26. doi: 10.1039/c4fo00290c. PMID: 25014672.

[5] Silletta MG, Marchioli R. Caffè rischio di malattie cardiovascolari: yin e yang [Coffee and cardiovascular disease risk: yin and yang]. Recenti Prog Med. 2008 Nov;99(11):533-7. Italian. PMID: 19209536.

[6] Glover FE, Caudle WM, Del Giudice F, Belladelli F, Mulloy E, Lawal E, Eisenberg ML. The association between caffeine intake and testosterone: NHANES 2013-2014. Nutr J. 2022 May 17;21(1):33. doi: 10.1186/s12937-022-00783-z. PMID: 35578259; PMCID: PMC9112543.

[7] Paz-Graniel I, Kose J, Babio N, Hercberg S, Galan P, Touvier M, Salas-Salvadó J, Andreeva VA. Caffeine Intake and Its Sex-Specific Association with General [8] Anxiety: A Cross-Sectional Analysis among General Population Adults. Nutrients. 2022 Mar 15;14(6):1242. doi: 10.3390/nu14061242. PMID: 35334898; PMCID: PMC8951500.

[9] Zhang WZ, Sun NN, Hu Y, Cao Y, Amber S. Caffeine Exposure Causes Immune Dysfunction and Intrauterine Growth Restriction Retardation in Rats. Biomed Environ Sci. 2022 Feb 20;35(2):170-173. doi: 10.3967/bes2022.025. PMID: 35197185.

[10] Fortier I, Marcoux S, Beaulac-Baillargeon L. Relation of caffeine intake during pregnancy to intrauterine growth retardation and preterm birth. Am J Epidemiol. 1993 May 1;137(9):931-40. doi: 10.1093/oxfordjournals.aje.a116763. PMID: 8317450.

[11] Purdue-Smithe AC, Kim K, Schliep KC, DeVilbiss EA, Hinkle SN, Ye A, Perkins NJ, Sjaarda LA, Silver RM, Schisterman EF, Mumford SL. Preconception caffeine metabolites, caffeinated beverage intake, and fecundability. Am J Clin Nutr. 2022 Apr 1;115(4):1227-1236. doi: 10.1093/ajcn/nqab435. PMID: 35030239; PMCID: PMC8970989.

[12] Poole R, Kennedy OJ, Roderick P, Fallowfield JA, Hayes PC, Parkes J. Coffee consumption and health: umbrella review of meta-analyses of multiple health outcomes. BMJ. 2017 Nov 22;359:j5024. doi: 10.1136/bmj.j5024. Erratum in: BMJ. 2018 Jan 12;360:k194. PMID: 29167102; PMCID: PMC5696634.

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